A PEPTIDE FOR TREATING A PATIENT HAVING A CONDITION MEDIATED BY NEUROTOXICITY, NEURODEGENERATION OR NEUROLOGICAL DAMAGE

摘要

The invention relates to a peptide for treating a patient having a condition mediated by neurotoxicity, neurodegeneration or neurological damage comprising one or more monomeric peptides of 8 to about 40 amino acids in length that bind to EPO receptor, each monomeric peptide comprising a sequence of amino acids X4X5XaXbX6XcXdX7 (SEQ ID NO: 47), wherein Xa is G or A; Xb is P or A; Xc is T or A; Xd is selected from W, A, and F; X4 is selected from R, H, Y, L, and W, or X4 is nonexistent; X5 is selected from F, M, and I; X6 is independently selected from the 20 genetically coded L-amino acids of the stereoisomeric D-amino acids; and X7 is selected from D, V, E, I, and L.