MEDICAMENT CONTAINING AN EFFECTOR OF THE GLUTATHIONE METABOLISM TOGETHER WITH α-LIPOIC ACID FOR USE IN KIDNEY REPLACEMENT THERAPY

摘要

A medicament comprising an effector of the glutathione metabolism together with α-lipoic acid, its salts and/or its prodrugs as a combination preparation for the simultaneous, separate or sequential treatment of a disturbance of the thiol-disulfide status in kidney replacement therapy, and syndromes in which a disturbance of the thiol-disulfide status of immune cells occurs, where as an effector ambroxole having the general formula I its salts and/or its prodrugs is used, characterized in that the dose of α-lipoic acid, its salts and/or its prodrugs for human medicinal administration to the patient is between 30 and 1200 mg/d and in that the dose of ambroxole, its salts and/or its prodrugs for human medicinal administration to the patient is between 7.5 and 90 m g/d.