Objective: To assess the effects of hormone replacement therapy (HRT) on plasma lipid levels and hormone levels in postmenopausal women. Methods: A total of 108 Chinese postmenopausal women with hyperlipodemia (mean age (65.3±0.7) years) were randomly divided into 3 groups (group Ⅰ , Ⅱ and Ⅲ). Patients in group Ⅰ received exclusive estrogen therapy (Premarin), those in group Ⅱ received combined therapy with estrogen and progestrone (Livial), and those in group Ⅲ were treated with placebo. At the end of 3 and 6 months of the therapy, the serum sex hormone and lipid levels were determined and compared with the baseline levels. Results: After 6 months’ therapy, in group Ⅰ, a statistically significant (P < 0.01) decrease or increase vs the baseline was observed in serum lipid levels: the tatal cholesteror (TC) dropped by 12.8%, triglyceride (TG) by 17%, low-density lipoprotein cholesterol (LDL-ch) by 29%, and high-density lipoprotein cholesterol (HDL-ch) was elevated by 14.6%. In group Ⅱ, TC levels was decreased by 8.7%, TG by 15.6%, LDL-ch by 33% and HDL-ch by 28.3%. The serum estradiol (E2) levels in both group Ⅰ and Ⅱ was increased significantly (P < 0.01). Conclusion: Estrogen replacement therapy (ERT) benefits the lipoprotein metabolism in postmenopausal women with hyperlipodemia but when progestational is added to the ERT, the beneficial effect of estrogen on blood lipids was reduced.
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