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Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous anti-body solutions
Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous anti-body solutions
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机译:疏水相互作用色谱法或铰链区修饰用于生产均质抗体溶液的用途
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摘要
Disclosed are methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising; connecting peptides of the invention.
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