Compounds derived from pyrimidine - 2.4 - dione and Co. - 2.4 - dione and Pharmaceutical composition comprising such compounds to treat Diseases mediated by HIV, AIDS or Arc

摘要

Relating to compounds of formula (i), where a is chr3 = ChR2, ch2r3ch2r2, CH2; r1 is alkyl, (ii) (C1 - C6); R2 is H, alkyl (C1 - C3), haloalquilo (C1 - C3), alquenilo (C2 - C6), nrarb X1, among others; is o or s; x2 is or if it is chr3 = ChR2, X2 or NRD; R3 is H or alkyl (C1 - C3); R4 is Halogen, alkyl (C1 - Cycloalkyl (C6), C3 C6), haloalquilo (C1 - C6) or alkoxy (C1 - C6), ra and RB are h,Alkyl (C1 - C3) or acyl (C1 - C6); Rd is H, alkyl or acyl (C1 - C3) (C1 - C6); ar is phenyl substituted by 1 to 3 halogeno, cyano, alkoxy (C1 - C6); n is 1 to 3. Preferred compounds are: 3 - [6 - bromo - 3 - (2 - [- 1 - methyl - tetrahydro - pyrimidin-2-yl) - 2 - phenoxy] - 5 - fluoro chloro BENZONITRILE, 3 - [3 - (4 - amino - 2 - oxo - 2H - pyrimidine - 1 - methyl) - 6 Bromine Fluorine - 2 - phenoxy] - 5 - chloro BENZONITRILE; among others.It also relates to a Pharmaceutical Composition and a preparation method thereof. These compounds inhibit hiv-1 reverse transcriptase, and are useful in the Prevention and Treatment of HIV, AIDS and / or Arc