Pharmaceutical composition containing an antagonist of chemokine receptor 1 (ccr1), a glucocorticoid receptor agonist and a B2 agonist

摘要

Refers to a Pharmaceutical composition containing: (a) an antagonist of chemokine receptor 1 (ccr1) as the compound of formula (i) that can be found in a number of 0.To 10000ug 1ug in Composition, where R1 is Halogen, cn or haloalquilo (C1 - C6); X, y, Z are each a Union, - O -, - NH -, - CH2 - or - C (o) - alkyl; R2 = or (C1 - C6); R3 is H, hydroxyl or NH2; R8 is H or alkyl (C1 - C6); is a Union (C1 - C3) or alkyl; R4 is H, Oh, Oxo, among others; R5 is H, Halog Eno, hydroxyl or alkoxy (C1 - C6); R9 is Halogen, NS,Alkoxy (C1 - C3) or haloalquilo (C1 - C3); Q is 0 OR 1; m, N and T are 0, 1 or 2; being Preferred compounds: N - (2 - [(2S) - 3 - (5 '- chlorine - 1 h, 3H - spiro [1 - benzofuran - 2,4' - piperidin] - 1 '- yl) - 2-hydroxypropyl] oxy] - 4 - hydroxyphenyl) acetamide, trifluoroacetate Salt of N - (2 - [(2S) - 3 - (5' - chlorine - 1 H - spiro [benzodioxol - 2.4 - 1.3 ' - piperidin] - 1 '- yl) - 2-hydroxypropyl] oxy] - 4 - hydroxyphenyl) acetamideAmong others; (b) a glucocorticoid receptor agonist such as budesonide is found in a number of 0.1ug to 1000ug in Composition; and (c) a B2 agonist such as formoterol, indacaterol, among others, to be found in a number of 0.1ug to 1000ug.Said composition is administered by inhalation to be useful in the treatment of chronic obstructive pulmonary disease, asthma