5-htma and D3 dual receivers

摘要

About benzo [D] isoxazol-3-i l-piperidin-1-l derivatives from formula (I): where x is halogen, cyanogen, pitch (C1-C6),Among others, n is 0, 1, 2 or 3; R1 is h or tar (C1-C6);R2 is (a) or (b);R3 is h, tar (C1-C6),Alquenilo（C2-C6），There are others The most popular compounds are: 4N trans (4 - {2 - [4 - (6-fluoro-benzo [D] isoxazol-3-il) - piperidin-1-il] - ethyl} - cyclohexil) - acetyl, trans - (4 - {2 - [4 - (6-fluoro-benzo [D] isoxazol-3-il) - piperidin-1-il] - ethyl} - cyclohexil) - o-tetrahydrogen-piran-carilico, N-trans - (4 - {2 - [4 - (6-fluoro-benzo [D] isozaxol-3-il) - piperidin-1-il] ethyl} - cyclohexyl) - 3-methyl-prophet, etc. He also mentioned a formula and a way to prepare a pharmacological composition. These compounds are double modulators of serotonin collector 5-htma and dopamine D3 receptor, and are useful in the treatment of mental rotors such as depression,2. anxiety, etc.