T CELL RECEIVER (TCR), TCR CONNECTING TO A HLA-A * 02 COMPLEX, TCR ANTI-CD3 FUSION MOLECLE, NUCLEIC ACID, EXPRESSION VECTOR, CELL, UN-NATURAL AND / OR PURPOSE CELL / OR DESIGNED, PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT OF A HUMAN INDIVIDUAL IN REQUEST FOR THIS, INJECTABLE FORMULATION FOR ADMINISTRATION TO A HUMAN INDIVIDUAL, AND METHOD OF PRODUCTION OF A TCR

摘要

The present invention relates to hla-a * 02 gvydgrehtv-restricted peptide (tcrs) binding t-cell receptors (sequence id: 1) derived from mage a4 germline cancer antigen. said tcrs may comprise unnatural mutations within the alpha and / or beta variable domains relative to a mage a4 natural tcr. The compounds of the invention are particularly suitable for use as novel immunotherapeutic reagents for the treatment of malignant disease.