Tetrahydrofluorocarbon derivatives as modulators of mhr1 receivers

摘要

It refers to the alternative formula (I) of tetrahydrofluoroalkane derivatives,Wherein: R1 and R2 are h, tar (C1-C8),Alcoxi（C1-C4），Among others, R3, R4 and R5 are h, F, Cl, Br, etc.; L1 is C (R34) (R35),C（R36）（R37）C（R38）（R39），Bicycle (C3-C6),R34 to R39 are each h, asphalt (C1-C8);X is O, C (r43) (r43 ';R6, R6',R7, R7',R43 and r43 are h, F, tar (C1-C8), respectively,R8 is, inter Alia, h, bitumen (C1-C8);L2 is a link, C (R44) (R45),R44 and R45 are h, asphalt (C1-C8);A is a 5-6 member aromatic ring, which can include up to 2 heteromorphic organisms selected from n or s, which can be replaced by H, F, Cl, Br, etc.; L3 is a 1-4 member link or can, whose members are selected from O, s, SO2, etc.; B is a tar (C1-C6),2. Alcox (C1-C4) - tar (C1-C4);1. Hydroxy asphalt (C1-C6);There are others The most popular compounds are n - ((s) - 6-pirrolidin-1-ilmerhy-1,2,3,4 - (s) - 1 - (tetrahydrofuran-2-il) methyl] - benzamida, N-methyl-N - ((s) - 6-pirrolidin-1-ilmermerhy-1,2,3,4-tetrahydro-naftlen-2-il) - 4 - (s) - 1 - (tetrahydro-naftlen-2-il) - benzofuran. He also mentioned a preparation procedure and a drug synthesis containing these substances. These compounds are modulators of MCH receptors,Specially formulated MCHR1 activity is a useful tool for the treatment and / or prevention of obesity, diabetes, degreasing, fat sterility, etc