Treatment of the symptoms of bladder irritation

摘要

1-(pyrid-4-ylamino)-indole (I), its salts and derivatives convertible to (I) in vivo are used to prepare a composition for treating symptoms of irritation of the bladder. An independent claim is included for the use of indole derivatives of formula (II) and their salts, to prepare a composition for treating symptoms of irritation of the bladder. R = group convertible into hydrogen by biotransformation. [Image] ACTIVITY : Uropathic. MECHANISM OF ACTION : (I) acts on the afferent pathway, reducing the frequency of contractions in the isolated bladder but not altering the maximum pressure of these contractions. (I) was tested using rat bladder model described in . (I), infused as a solution in saline, caused a dose-dependent reduction in the number of bladder contractions, e.g. at a dose of 3.5 mg/kg it reduced the number of contractions to 15% of that in a control. This concentration had no significant effect on the maximum pressure of those isovolumetric, rhythmic contractions that were not inhibited.