首页> 中文期刊> 《癌症生物学与医学:英文版》 >A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer

A multi-institutional retrospective study of hyperthermic plus intravesical chemotherapy versus intravesical chemotherapy treatment alone in intermediate and high risk nonmuscle-invasive bladder cancer

         

摘要

Objective:To compare the efficacy and safety of hyperthermic intravesical chemotherapy(HIVEC)and intravesical chemotherapy(IVEC)in patients with intermediate and high risk nonmuscle-invasive bladder cancer(NMIBC)after transurethral resection.Methods:We included 560 patients diagnosed with primary or recurrent NMIBC between April 2009 and December 2015 at 1 of 6 tertiary centers.We matched 364 intermediate or high risk cases and divided them into 2 groups:the HIVEC+IVEC group[chemohyperthermia(CHT)composed of 3 consecutive sessions followed by intravesical instillation without hyperthermia]and the IVEC group(intravesical instillation without hyperthermia).The data were recorded in the database.The primary endpoint was 2-year recurrence-free survival(RFS)in all NMIBC patients(n=364),whereas the secondary endpoints were the assessment of radical cystectomy(RC)and 5-year overall survival(OS).Results:There was a significant difference in the 2-year RFS between the two groups in all patients(n=364;HIVEC+IVEC:82.42%vs.IVEC:74.18%,P=0.038).Compared with the IVEC group,the HIVEC+IVEC group had a lower incidence of RC(P=0.0274).However,the 5-year OS was the same between the 2 groups(P=0.1434).Adverse events(AEs)occurred in 32.7%of all patients,but none of the events was serious(grades 3–4).No difference in the incidence or severity of AEs between each treatment modality was observed.Conclusions:This retrospective study showed that HIVEC+IVEC had a higher 2-year RFS and a lower incidence of RC than IVEC therapy in intermediate and high risk NMIBC patients.Both treatments were well-tolerated in a similar manner.

著录项

  • 来源
    《癌症生物学与医学:英文版》 |2021年第1期|P.308-317|共10页
  • 作者单位

    Department of Abdominal Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095 ChinaThe First Affiliated Hospital of Jinan University the First Clinical Medical College of Jinan University Guangzhou 510630 China;

    Department of Urinary Surgery Henan Provincial People’s Hospital Zhengzhou 450003 China;

    Department of Urinary Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095 China;

    Department of Urinary Surgery Henan Cancer Hospital Zhengzhou 450008 China;

    Department of General Surgery Huaihe Hospital of Henan University Kaifeng 475000 China;

    Department of Urinary Surgery Gaozhou People’s Hospital Maoming 525200 China;

    Department of General Surgery The Second Affiliated Hospital of Zhengzhou University Zhengzhou 450014 China;

    Department of Abdominal Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095 China;

    Department of Abdominal Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095 China;

    Department of Abdominal Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095 China;

    Department of Abdominal Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095 China;

    Department of Abdominal Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095 China;

    Department of Abdominal Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095 China;

    Department of Abdominal Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095 China;

    Department of Abdominal Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095 China;

    Department of Abdominal Surgery Affiliated Cancer Hospital&Institute of Guangzhou Medical University Guangzhou 510095 China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 肿瘤学;
  • 关键词

    Nonmuscle-invasive bladder cancer; intravesical chemotherapy; hyperthermia; chemohyperthermia; retrospective study;

    机译:非血液侵袭性膀胱癌;膀胱内化疗;热疗;化学高疗医疗;回顾性研究;
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号