首页> 外国专利> PROTEINS BINDING THE CROSS-BETA STRUCTURE-CONTAINING AMYLOID, AND METHOD FOR MODULATING THE CROSS-BETA STRUCTURE, THEIR EDUCATION AND RELATED TOXICITY

PROTEINS BINDING THE CROSS-BETA STRUCTURE-CONTAINING AMYLOID, AND METHOD FOR MODULATING THE CROSS-BETA STRUCTURE, THEIR EDUCATION AND RELATED TOXICITY

机译：结合含跨谱结构的淀粉的蛋白，以及调控跨谱结构的方法，其教育和相关毒性

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摘要

The invention relates to cross- beta structures and the biological role of these cross- beta structures. Methods for modulating extracellular protein degradation and/or protein clearance or for diminishing plaques involved in conformational diseases by modulating cross- beta structure formation and/or tissue plasminogen activator (tPA)-like activity are disclosed, as well as diagnostic methods by visualising cross- beta structures.

机译：本发明涉及交叉β结构以及这些交叉β结构的生物学作用。公开了通过调节交叉β结构的形成和/或组织纤溶酶原激活物（tPA）样活性来调节细胞外蛋白质降解和/或蛋白质清除率或减少构象疾病中噬菌斑的方法，以及通过可视化交叉蛋白的诊断方法。 beta结构。

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公开/公告号AT417605T

专利类型
公开/公告日2009-01-15

原文格式PDF
申请/专利权人 CROSSBETA BIOSCIENCES B.V.;
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申请/专利号AT20030762927T
发明设计人 GEBBINK MARTIJN;BOUMA BAREND;KRANENBURG ONNO;KROON LOUISE;
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申请日2003-07-08
分类号A61K31;G01N33/50;A61K31/195;A61K31/197;A61K31/198;A61K31/7004;A61K38;A61K38/49;A61K39/395;A61K45;A61P3/10;A61P7/02;A61P7/04;A61P9/10;A61P25;A61P25/08;A61P25/16;A61P25/28;A61P29;A61P31;A61P31/04;A61P35;A61P37;A61P37/06;C12N9/72;G01N33/15;G01N33/53;G01N33/68;
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入库时间 2022-08-21 19:24:39

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