Transgenic animal model for Alzheimer's disease.

摘要

THE INVENTION PROVIDES NON-HUMAN TRANSGENIC ANIMALS THAT SHOW AS MANY APP FEATURES AS LINKED TO THE TAU, FOR EXAMPLE, HISTOLOGICAL CHARACTERISTICS, OF THE PATHOLOGY OF THE DA (ALZHEIMER DISEASE), AND PREFERENTIALLY CHARACTERISTICS. NON-HUMAN TRANSGENIC ANIMALS EXPRESSLY EXPRESS A HUMAN APP THAT INCLUDES THE SWEDISH MUTATION OR THE SWISS MUTATION COMBINED WITH ONE OR MORE ADDITIONAL MUTATIONS, IN PARTICULATE THE LONDON MUTATION. IT IS CHECKED THAT THE LEVEL TO WHICH THE TRANSGEN IS EXPRESSED IN THE TRANSGENIC ANIMAL, FOR EXAMPLE, THE LEVEL OF THE TRANSGEN ARNM, IS AN IMPORTANT FACTOR TO OBTAIN THE PATHOLOGY OF DA IN ANIME. IT HAS BEEN CHECKED THAT SOME TRANSGENIC MOUSES EXPRESSING SUCH HUMAN APP MUTED UNDER CONTROL OF THE THY-1 PROMOTING ELEMENT DEVELOP A PATHOLOGICAL PHENOTYPE THAT GOES BEYOND THE DESCRIBED ABOVE BY GAMES ET AL. [NATURE 373, 523-527, (1995)], BY COMBINATION OF APP CHARACTERISTICS AND LINKED TO TAU OF THE EA'S PATHOLOGY. IN ADDITION, IT HAS BEEN OBSERVED THAT THE MOUSES PRESENT THE CHARACTERISTIC CHANGES OF THE EA, WHICH HAD NEVER BEEN DESCRIBED ABOVE WITH REFERENCE TO TRANSGENIC ANIMALS.