Citrullinated peptides derived from fibrin recognized by specific autoantibodies of rheumatoid arthritis and uses thereof.

摘要

Peptide recognized by antiproteínas autoantibodies citrullinated (AAPC) present in the serum of patients affected by rheumatoid polyarthritis (RP), characterized in that it comprises at least one citrullyl residue and that is selected from the group consisting isolated by: a) a peptide defined by the sequence X 1PAPPPISGGGYX 2AX 3 (SEQ ID NO: 1) wherein X 1, X 2 and X 3 each represents a citrullyl residue or an arginyl residue and at least one of X 2 or X 3 radicals is a citrullyl residue; b) a defined by the sequence GPX 1VVEX 2HQSACKDS (SEQ ID NO peptide: 2) wherein X 1 and X 2 each represents a citrullyl residue or an arginyl residue and at least one of X 1 or X 2 moieties is a citrullyl residue; c) defined by a sequence SGIGTLDGFX1HX2HPD (SEQ ID NO peptide: 3) wherein X1 and X2 each represents a citrullyl residue or an arginyl and at least one of X 1 or X 2 moieties moiety is a citrullyl residue; d) a defined by the sequence VDIDIKIX1SCX2GSCS (SEQ ID NO peptide: 4) wherein X1 and X2 each represents a citrullyl residue or an arginyl and at least one of the radicals X1 or X2 moiety is a citrullyl residue; e) defined by the sequence X1GHAKSX2PVX3GIHTS (SEQ ID NO peptide: 12) wherein X1, X2 and X3 each represents a citrullyl residue or an arginyl residue and at least one of the radicals X1, X2 or X3 is a moiety citrullyl ; f) a peptide comprising at least 5 consecutive amino acids, including at least one previous citrullyl residue, of one of peptides a) to e).