DERIVATIVES OF 1H-IMIDAZO (4,5-C) QUINOLINA FOR THE TREATMENT OF DEPENDENT DISEASES OF PROTEIN KINASE.

摘要

Use of a compound of formula 1 (See formula) where each of x and y is, independently of the other. 0 or 1, R is Hydrogen; lower alkyl; mono- or di-hydroxy-lower alkyl; C6-C14 aryl which is substituted or not substituted by one to three substituents selected from lower alkyl, halo-lower alkyl, halogen, amino, lower alkanoylamino. lower alkoxy, and nitro; C3-C8 cycloalkyl; or furanoyl-lower alkyl; R1 is phenyl or phenyl-lower alkyl, each of which, in the phenyl functional group, is substituted or not substituted by up to three functional groups independently selected from halogen, especially fluoro, chloro, bromo or iodo, lower alkyl, halo - lower alkyl, hydroxy, lower alkoxy, C6-C14 aryl, hydroxy-lower alkyl, amino. amino-lower alkyl, amidino, N-hydroxy-amidino, amidino-lower alkyl, N-hydroxyamidino-lower alkyl, cyano-lower alkyl, and cyano; or is C3-C6 cycloalkyl, or hydroxy-C3-C8 cycloalkyl,: X is C = O; R2 is Hydrogen, R3 is Hydrogen, lower alkyl, halo, lower alkoxy, or unsubstituted or substituted by C6-14 aryl unsubstituted or substituted by halo, halo-lower alkyl, hydroxy, amino, lower alkoxy, hydroxy-lower alkyl, amino-lower alkyl, cyano, cyano-lower alkyl, amidino, N-hydroxyamidino, amidino-lower alkyl or N-hydroxyamidino-lower alkyl; R4 is hydrogen or halo. R5 is Hydrogen or lower alkoxy, and R9 is Hydrogen, halo. C8-C14 aryl, C3-C8 cycloalkyl, amino, lower alkylamino, lower hydroxyalkylamino, or C6-C14 aryl carbonylamino; or a pharmaceutically acceptable salt thereof, for the manufacture of a pharmaceutical preparation for the treatment of a disease that depends on protein kinase.