BENZOXAZINES FOR THE PREVENTION OR TREATMENT OF HYPERALGESIA INDUCED BY MORPHINIC COMPOUNDS.

摘要

Use of at least one compound of the following general formula (I): (See formula) in which: - R5 represents O or no group; - R 6 represents H or an alkyl group containing from 1 to 6 carbon atoms; - n represents an integer from 2 to 4; - j represents an integer that varies from 1 to n; - Rj, identical or different for each substituted carbon, represents H or an alkyl group containing from 1 to 6 carbon atoms; - R7 represents a phenyl group optionally substituted with one or several groups, identical or different, chosen from the list comprising H, an alkyl group containing 1 to 6 carbon atoms, an alkoxy group containing 1 to 6 atoms of carbon, a trifluoromethyl group, or a halogen atom; - R8, R9, R10, R11 identical or different represent H, an alkyl group containing from 1 to 6 carbon atoms, an alkoxy group containing from 1 to 6 carbon atoms, a trifluoromethyl group, or a halogen atom; or of its pharmaceutically acceptable salts, for the preparation of a medicament intended for the prevention or treatment of hyperalgesia due to morphine analgesics, in an individual who has received an administration of a morphine analgesic.