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Benzoxazines for the prevention or treatment of hyperalgesia induced by morphine compounds
Benzoxazines for the prevention or treatment of hyperalgesia induced by morphine compounds
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机译:苯并恶嗪用于预防或治疗吗啡类化合物引起的痛觉过敏
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摘要
Use of a nefopam compound (I), or its salt, for the preparation of a drug to prevent or treat the acute tolerance of morphine or the hyper-analgesic effect due to morphine administration. Use of a nefopam compound of formula (I), or its salt, for the preparation of a drug to prevent or treat the acute tolerance of morphine or the hyper-analgesic effect due to morphine administration. R 5O or is absent; R 6 and R jH or 1-6C alkyl; n : 2-4; j : 1-n; R 7phenyl, optionally substituted one or more times by H, 1-6C alkyl, 1-6 alkoxy, CF 3 or halo; and R 8-R 11H, 1-6C alkyl, 1-6 alkoxy, CF 3 or halo. An independent claim is also included for a product containing (I) and/or a morphine analgesia (to induce an analgesic effect), where (I) prevents or treats the acute tolerance of morphine or hyper-analgesic effect due to morphine. [Image] ACTIVITY : Analgesic. MECHANISM OF ACTION : N-methyl-d-aspartate receptor antagonist.
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机译:奈福m化合物(I)或其盐在制备用于预防或治疗吗啡的急性耐受性或由于吗啡给药引起的镇痛作用的药物中的用途。式(I)的奈福opa化合物或其盐在制备用于预防或治疗吗啡的急性耐受性或由于吗啡给药引起的镇痛作用的药物中的用途。 R 5O或不存在; R 6和R jH或1-6C烷基; n:2-4; j:1-n; R 7苯基,任选地被H,1-6C烷基,1-6烷氧基,CF 3或卤素取代一次或多次; R 8 -R 11H,1-6C烷基,1-6烷氧基,CF 3或卤素。对于包含(I)和/或吗啡镇痛剂(以引起镇痛作用)的产品也包括独立权利要求,其中(I)预防或治疗吗啡的急性耐受性吗啡或镇痛作用。 [图像]活动:止痛药。作用机理:N-甲基-d-天冬氨酸受体拮抗剂。
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