RETINOIDS FOR THE TREATMENT OF THE EFFECT.

摘要

A compound according to the structural formula (VI): ** see formula ** or a pharmaceutically acceptable salt, solvate or hydrate thereof, where: n is an integer from 0 to 2; R 1 is -C (= O) -R 9; R 9 is hydroxy or alkoxy; and R 2 is: (a) - (CR 10 R 11) m-Yp-R 12; m is an integer from 1 to 10; p is 0 or 1; R 10 and R 11 are independently hydrogen, alkyl, hydroxyl or hydroxyalkyl; Y is -O-, -S (O) q- or -NR 13 -; and q is an integer from 0 to 2; and R 13 is hydrogen or alkyl; R 12 is hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, arylalkyl, heteroaryl, heteroaryl-alkyl, acyl, alkoxycarbonyl, carbamoyl, substituted cycloalkyl, heteroalkyl, cycloalkyl substituted with heteroalkyl, hetero-substituted cycloalkyl, cycloalkyl-hetero-substituted alkyl or heterocyclylalkyl; with the proviso that, if p = 0, R 12 is not hydrogen or alkyl; (b) heteroaryl; (c) -Z-L, where: Z is -CR 14 = CR 15 -, -C - = - C-, -O-, -NR 16 - or -S (O) q-; R 14, R 15 and R 16 are independently hydrogen or alkyl; and L is heteroaryl, heteroarylalkyl or heteroalkyl; or (d) -CR 14 = CR 15 -L1, where L1 is S (O) 2R 17 or SO2NR 18 R 19, where R 17 is alkyl and R 18 and R 19 are independently hydrogen or alkyl; R 3 is hydrogen; and t is 1 or 2.