INTRAVENOUS PROPOFOL EMULSION COMPOSITIONS THAT HAVE CONSERVATIVE EFFECTIVENESS.

摘要

A composition of stable Propofol oil-in-water emulsions, intravenously administrable, comprising triglyceride oils; emulsifiers that are selected from purified and slightly modified natural phosphatides; Water; agents that modify tonicity; and preservative system comprising monoglyceryl ester of lauric acid (monolaurin) and a member selected from (a) capric acid and / or its soluble alkaline salts or its monoglyceryl ester (monocaprine); (b) EDTA sa and (c) capric acid and / or its soluble alkaline salts or its monoglyceryl ester (monocaprine) and EDTA salt.