Effects of remifentanil combined with propofol intravenous target controlled anesthesia on inflammatory reaction, oxidative stress and neurotransmitter in patients undergoing surgery in cerebral surgery

摘要

cqvip:Objective:To investigate the effect of remifentanil combined with propofol intravenous target-controlled anesthesia on inflammatory reaction, oxidative stress and neurotransmitter in patients undergoing cerebral surgery.Methods: A total of 86 cases of cerebral surgery patients were divided into control group (n=43) and study group (n=43) based on random lottery method, the patients in the control group was given fentanyl combined with propofol intravenous target controlled anesthesia, and the study group patients were given remifentanil and propofol intravenous target controlled anesthesia, the levels of inflammatory factors, oxidative stress and neurotransmitter levels of the two groups were compared before anesthesia induction (T0), tracheal intubation (T1) and extubation (T2) at three time points.Results:No statistical difference of the levels of hs-CRP, TNF-α, MDA, SOD, NE, ALD and PRA between the two groups at T0 moment (P>0.05). Compared with the levels of T0 moment in the same group, hs-CRP, TNF-α, MDA, NE, ALD and PRA levels in the two groups of T1 and T2 increased at different degrees, and the level of SOD decreased (P<0.05). The levels of hs-CRP and TNF-α at the time of T1 and T2 in the study group were (13.18±2.29) mg/L, (70.92±18.97) ng/L, (15.53±4.78) mg/L and (89.15±29.56) ng/L, respectively, which were significantly lower than those of the control group at the same time (allP<0.05). The MDA levels at the T1 and T2 levels of the study group were (3.69±0.42) mmol/L and (4.74±0.51) mmol/L, respectively, which were significantly lower than those of the control group at the same time (allP<0.05). The SOD level were (67.66±9.50) U/mL and (63.21±5.64) U/mL, respectively, which were significantly higher than those of the control group at the same time (allP<0.05).The NE, ALD and PRA levels at the T1 and T2 levels of the study group were (310.29±20.38) ng/mL and (314.62±19.61) ng/mL, (220.89±15.21) pg/mL and (233.62±15.85) pg /mL and (4.75±1.28) ng/mL/24 h and (4.87±1.32) ng/mL/24 h, respectively, which were significantly lower than the control group at the same time (allP<0.05).Conclusion: Remifentanil combined with propofol target controlled anesthesia can effectively reduce the inflammatory response and improve the oxidative stress status in patients undergoing cerebral surgery, and have little influence on neurotransmitter indexes, which has an important clinical value.