NAFTIRIDONES AND QUINOLONAS 7-AMINO ALQUILIDENIL-HETEROCICLICAS.

摘要

A compound having a structure according to formula I ** (See formula) ** in which: n is an integer from 1 to 3; m is an integer from 1 to 3; z is an integer from 0 to 3; R is hydrogen, hydroxy or alkoxy; R 2 is hydrogen; R3 and R4 are independently hydrogen, halogen, amino, hydroxy, alkoxy, alkylthio, alkyl, alkenyl or alkynyl; R5 is hydrogen, hydroxyl, halogen, alkyl, aryl, alkoxy or alkylthio; and R6 is alkyl, hydroxy, alkoxy, alkylthio, alkenyl, alkynyl, aryl, alkoxyimino or halogen; or R5 and R6 join to form a 4- to 7-membered carbocyclic ring in which each carbon atom of the ring may be optionally substituted with R 12; R 12 is halogen, amino, hydroxy, alkoxy, alkylthio, alkyl, alkenyl, alkynyl, oxo, alkoxyimino or hydroxyimino; E is good: 1) ** (See formula) ** in which: q is an integer from 1 to 3; R7 and R8 are independently hydrogen or alkyl; or R7 and R8 join to form a 3 to 6 member carbocyclic ring; or any one between R7 or R8 can be independently linked with any one between R9 or R10 to form a heterocyclic ring containing the nitrogen atom to which R 9 or R 10 is attached; R9 and R10 are independently hydrogen, alkyl, acyl, alkoxycarbonyl or sulfonyl; or R9 and R10 join to form a heterocyclic ring containing the nitrogen atom to which they are attached; or 2) ** (See formula) ** in which: q is as defined above; R7 and R8 are independently hydrogen or alkyl; or R7 and R8 join to form a 3 to 6 member carbocyclic ring; R9 is hydrogen, alkyl, acyl, alkoxycarbonyl or sulfonyl; or 3) alkenyl; A is N or C (R11); R11 is hydrogen, alkyl, halogen, hydroxyl, alkoxy, alkylthio or cyano; X is C or N, such that if X is C, a is a double bond and b is a simple link, if X is N, a is a single link and b is a double bond; Y is N (R1) or C (R1), with the proviso that when Y is N (R1), X is C, and when Y is C (R1), X is N; and R1 is cycloalkyl (C3-C6), heterocycloalkyl (C4-C6), alkyl, alkene, a 6-membered aryl or a 6-membered heteroaryl, with the proviso that if A is C (R 11), X is C and Y is N (R 1), then R 11 and R 1 can be joined to form a 6-membered heterocyclic ring, if A is C (R 11), X is C and Y is N (R 1), then R 2 and R 1 can be joined to form a monocyclic or bicyclic heterocyclic ring, and if A is C (R11), X is C and Y is N (R1), then R2 and R can be joined to form a heterocyclic ring of 5 members; or an isomer, diastereomer or optical enantiomer thereof; a pharmaceutically acceptable salt or hydrate thereof.