AMIDA DERIVATIVES OF ACID N- (PHENYL-OXAZOL-4-ILMETOXIMETIL) -CICLOHEXIL-SUCCINICO AND RELATED COMPOUNDS AS PPAR LIGANDS (ACTIVATED RECEPTORS FOR PEROXISOM PROLIFERATORS) FOR THE TREATMENT OF HYPERLIPETEM.

摘要

Compounds of formula I ** see formula ** in which they mean: ring A cycloalkanediyl- (C3-C8), cycloalkenodiyl- (C3-C8), in which in the rings of cycloalkanediyl or cycloalkenodiyl one or more carbon atoms they can be substituted by oxygen atoms; R1 and R2, independently of each other, H, F, Cl, Br, CF3, OCF3, alkyl- (C1-C6), O-alkyl- (C1-C6), SCF3, SF5, OCF2-CHF2, aryl- ( C6-C10), aryloxy- (C6-C10), OH, NO2; or R1 and R2, together with the phenyl, pyridine, 1-H-pyrrole, thiophene or furan, aryl- (C6-C10), heteroaryl- (C5-C11) bicyclic ring partially saturated or unsaturated; R3 H, alkyl- (C1-C6), cycloalkyl- (C3-C8), alkyl- (C1-C3) -cycloalkyl- (C3-C8), phenyl, alkyl- (C1-C3) -phenyl, heteroaryl- ( C5-C6), alkyl- (C1-C3) -heteroaryl- (C5-C6) or alkyl- (C1-C3) which is totally or partially substituted by F; W CH, N, if o = 1; W O, S, NR9, if o = 0; X-alkanediyl- (C1-C6), in which in the alkanediyl group one or more carbon atoms may be replaced by oxygen atoms; And CO, SO, SO2; n 0-2; R4 H, F, alkyl- (C1-C6); R5 H, F, alkyl- (C1-C6); R6 H, F, alkyl- (C1-C6); R5 and R6, together with the C atoms that carry them, cycloalkane- (C3-C8) -1,2-diyl; R7 H, alkyl- (C1-C6), alkenyl- (C2-C6), alkynyl- (C2-C6), O-alkyl- (C1-C6), O-alkenyl- (C2-C6), Oalkynyl- ( C2-C6), cycloalkyl- (C3-C8), aryl- (C6-C10), heteroaryl- (C5-C11), O-cycloalkyl- (C3-C8), O-phenyl, NR10R11 which may be substituted by O -alkyl- (C1-C6), O-alkenyl- (C2-C6), O-alkynyl- (C2-C6), O-cycloalkyl- (C3-C8), O-phenyl, O-heteroaryl- (C5- C11), and in which cycloalkyl- (C3-C8), phenyl and heteroaryl- (C5-C11) may also be substituted by alkyl- (C1-C6), optionally unsubstituted or totally or partially substituted by F, O- alkyl- (C1-C6), optionally unsubstituted or totally or partially substituted by F, Cl, Br, I, OH, NR10R11, CO-alkyl- (C1-C6), CO-aryl- (C6-C10), COheteroaryl - (C5-C11), C (O) -O-alkyl- (C1-C6), C (O) -O-aryl- (C6-C10), C (O) -O-heteroaryl- (C5-C11 ), SO2-alkyl- (C1-C6), SO2-aryl- (C6-C10), SO2-heteroaryl- (C5-C11), and the alkyl, aryl and heteroaryl can also be substituted by alkyl- (C1-C6) or phenyl; R6 and R7, along with the atom of C that carry them. cycloalkane- (C3-C8) -1,1-diyl; R8 H, alkyl- (C1-C6); R9 H, alkyl- (C1-C6) which is unsubstituted or substituted by phenyl and phenyl; R10 H, alkyl- (C1-C6), phenyl, CO-alkyl- (C1-C6), CO-aryl- (C6-C10), CO-alkyl- (C1-C6) -aryl- (C6-C10) , CO-heteroaryl- (C5-C11), C (O) -O-alkyl- (C1-C6), C (O) -O-alkyl- (C1-C6) -aryl- (C6-C10), C (O) -O-aryl- (C6-C10), C (O) -O-heteroaryl- (C5-C11), SO2-alkyl- (C1-C6), SO2-alkyl- (C1-C6) -aryl - (C6-C10), SO2-alkyl- (C1-C6) -SO2-alkyl- (C1-C6), SO2-aryl- (C6-C10), SO2-heteroaryl- (C5-C11), and may also be alkyl, aryl and heteroaryl substituted by (C 1 -C 6) alkyl or phenyl. R11 H, alkyl- (C1-C6) which is eventually substituted by phenyl, phenyl; R12 H, benzyl; as well as its physiologically acceptable salts and solvates.