METHODS OF DIAGNOSING CLINICAL SUBTYPES OF CROHN'S DISEASE

摘要

Provided herein is a method of diagnosing a clinical subtype of Crohn'sdisease (CD) by determining whether perinuclear anti-neutrophilantibody (pANCA) is present in a patient with CD, where the presence of pANCAindicates a clinical subtype of CD withfeatures of ulcerative colitis (UC). The present also provides a method ofdiagnosing clinical subtypes of Crohn's disease in a patient withCD by determing whether pANCA or speckling anti-pan polymorphonuclear antibody(SAPPA) is present in the patient with CD, wherethe presence of pANCA indicates a clinical subtype of CD with features ofulcerative colitis and where the presence of SAPPA indicatesa clinical subtype of CD having perforating, fistulizing or small bowelobstructive disease. The invention further provides a method ofdiagnosing clinical subtypes of Crohn's disease in a patient with CD bydetermining the presence or absence of ANCA, pANCA andSAPPA in the patient with CD and determining the presence or absence of anti-Saccharomyces cerevisiae antibodies (ASCA) in the patientwith CD, where the presnece of pANCA combined with the absence of ASCAindicate a clinical subtype of CD with features of UC, thepresence of SAPPA indicates a clinical subtype of CD having perforating orfistulizing disease or small bowel obstructive disease, and thepresence of ASCA combined with the absence of ANCA indicates a clincialsubtype of CD lacking features of ulcerative colitis and havingperforating or fistulizing disease or small bowel obstructive disease. Kitsfor diagnosing clinical subtypes of Crohn's disease, which containneutrophil and antigen specific for ASCA, also are provided.