2-ARYLALKYLTHIO -IMIDAZOLES, 2-ARYLALKENYL -THIO -IMIDAZOLES AND 2-ARYLALKINYL -THIO -IMIDAZOLES AS ANTI -INFLAMMATORY SUBSTANCES AND SUBSTANCES INHIBITING THE RELEASE OF CYTOKINE

摘要

2-Arylaklylthioimidazoles, 2-arylalkenylthioimidazolesand 2-arylalkynylthioimidazoles as antiinflammatoriesand inhibitors of cytokine releaseThe invention relates to 4-heteroaryl-5-phenylimidazolederivatives having 2-arylalkylthio, 2-arylalkenylthioand 2-arylalkynylthio substitution, of the generalformula I:(See formula I)in which Ar is a phenyl radical, Het is a heteroaromatic radical, A is an alkylene chain, R1 is analkylthio, alkylsulfinyl, alkylsulfonyl, sulfonamido oralkylcarbonyl group and R2 is an alkyl, hydroxyl,alkoxy, alkoxycarbonyl, sulfonamido, carboxyl, nitro oraminocarbonyl group or a halogen atom. n can be 1 or 2and m is 0 to 2. The compounds according to theinvention show antiinflammatory activity.