POLYMER BLENDS AS BIODEGRADABLE MATRICES FOR PREPARING BIOCOMPOSITES

摘要

The present invention provides bioerodable constructs for controlled releaseof bioactive materials. In a preferredmode, the constructs may be utilized adjacent to a biological surface. Theconstructs are based on a blend of two or more poly(ester-amide) polymers (PEA). Such polymers may be prepared by polymerization of adiol (D), a dicarboxylic acid (C) and an alpha-aminoacid (A) through ester and amide links in the form (DACA)n. An example ofa(DACA)n polymer is shown below in formula II.Suitable amino acids include any natural or synthetic alpha-amino acid,preferably neutral amino acids.