SUPRAMACROMOLECULAR POLYMER COMPLEXES PROVIDING CONTROLLED NITRIC OXIDE RELEASE FOR HEALING WOUNDS

摘要

A bio-adhesive supramacromolecular complex of the general formula (I):(see formula I)wherein R1 is an alkane unsubstituted or substituted with alkoxy groups;R2 is a lower alkane;R3 and R4 are long chain, optionally substituted, alkanes;W is a hydrogen-bond accepting functional group-containing entity;Y is a carboxylic acid ester or amide;Z is a linking group;T1, T2, T3 and T4 are terminal groups;m and n are integers selected from at least 25; and wherein P has a molecularweight of about 1 × 10 3 to 1 × 10 6 and Q has a molecular weightof about 1 × 10 3 to 1 × 10 7.The complex provides controlled nitric oxide release over a longer period oftime than priorart compounds in the healing of wounds and infections. Novel compositions,methods ofpreparation, skin coverings containing and medical use of the complexes aredescribed.