GENES REGULATING INTRACELLULAR CHOLESTEROL TRAFFICKING AS TARGETS FOR TREATMENT OF CHOLESTEROL-RELATED DISEASES

摘要

The present invention relates to novel genes, which regulate the intracellular cholesterol trafficking and which are involved in the development and/or progression of cholesterol- related diseases, disorders or conditions, such as neurological diseases, for example neurodegenerative conditions, e. g. Niemann-Pick type C disease. The invention also relates to the use of the said genes as novel drug targets for the development of medicaments useful to treat, prevent or ameliorate the said cholesterol-related diseases, disorders or conditions.