A VACCINE FOR TREATING OR PREVENTING PASTEURELLOSIS USING A YEAST SURFACE-EXPRESSION SYSTEM

摘要

The present invention relates to a vaccine composition for treating or preventing pasteurellosis using a yeast surface-expression system. In particular, the present invention relates to a recombinant nucleotide for the preparation of vaccine against pasteurellosis, comprising i) a nucleotide encoding an outer membrane peptide of Pasteurella multocida, ii) a nucleotide encoding an Aureobasidin A peptide, and iii) a nucleotide encoding an LTB (heat-labile enterotoxin subunit) peptide, a recombinant expression vector comprising the nucleotide, and a vaccine composition for treating or preventing pasteurellosis which is obtained by infecting a host cell with the vector. The vaccine composition prepared by the present invention can induce immune response by a simple immunization method including oral immunization, mucosal immunization, and intradermal immunization using a tattoo machine.