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PEG-COATED CORE-SHELL SILICA NANOPARTICLES AND METHODS OF MANUFACTURE AND USE
PEG-COATED CORE-SHELL SILICA NANOPARTICLES AND METHODS OF MANUFACTURE AND USE
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机译:PEG包覆的核壳二氧化硅纳米粒子及其制造和使用方法
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摘要
Described herein are PEG-coated, core-shell nanoparticles, which display reduced aggregation and/or reduced non-specific or undesired attachment characteristics. These fluorescent nanoparticle include: a silica-based core having an organic functional group that includes a mercapto substitituent, an organic fluorescent compound, a silica shell; and a silane-PEG compound. The silica shell of the nanoparticle encapsulates the silica-based core and the silane-PEG compound is conjugated to the silica shell.
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