首页> 外国专利> BIOMARKER FOR PURIFICATION OR IDENTIFICATION OF MESENCHYMAL STEM CELLS AND METHODS OF PURIFICATION OF MESENCHYMAL STEM CELLS BY USING IT

BIOMARKER FOR PURIFICATION OR IDENTIFICATION OF MESENCHYMAL STEM CELLS AND METHODS OF PURIFICATION OF MESENCHYMAL STEM CELLS BY USING IT

机译:纯化或鉴定间充质干细胞的生物标志物及使用该方法纯化间充质干细胞的方法

摘要

The present invention is related to biomarker for purification and idem i fi cat ion of mesenchymal stem cells and methods for purif ication of imseiichmai stem cells by using it. The present invention provides composition, apparatus and kit for separation or identification of MSCs comprising anti -fibroblast activation protein a (FAP a ). Also, the present invention provides the method for identification and purification of MSCs. In detail, the present invention provides the method for identification of MSCs comprising the steps of : contacting anti -FAP a antibody with test cell; detecting the forming of antigen-antibody complex of FAP a of the above test cell and the above anti -FAP a antibody. And the present invention provides the method for separation and purification MSCs comprising the steps of : forming antigen-antibody complex by contacting liquid biological media having MSC with anti-FAP a antibody; and collecting the above antigen-antibody complex.
机译:本发明涉及用于间充质干细胞的纯化和鉴定的生物标志物,以及使用该生物标志物纯化间质干细胞的方法。本发明提供了用于分离或鉴定包含抗成纤维细胞活化蛋白α(FAPα)的MSC的组合物,设备和试剂盒。另外,本发明提供了用于鉴定和纯化MSC的方法。详细地,本发明提供了用于鉴定MSC的方法,该方法包括以下步骤:使抗-FAP抗体与测试细胞接触;以及使抗-FAP抗体与测试细胞接触。检测上述测试细胞的FAP a和上述抗-FAP a抗体的抗原-抗体复合物的形成。并且本发明提供了分离和纯化MSC的方法,该方法包括以下步骤:通过使具有MSC的液体生物介质与抗FAP a抗体接触来形成抗原-抗体复合物;收集上述抗原-抗体复合物。

著录项

  • 公开/公告号WO2009031818A3

    专利类型

  • 公开/公告日2009-04-23

    原文格式PDF

  • 申请/专利权人 GENEXEL-SEIN. INC.;BAE SOHYUN;KIM HOEON;

    申请/专利号WO2008KR05191

  • 发明设计人 KIM HOEON;BAE SOHYUN;

    申请日2008-09-03

  • 分类号C07K16/18;C12N5/0775;

  • 国家 WO

  • 入库时间 2022-08-21 19:20:06

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