IMMEDIATE EARLY GENE ARC INTERACTS WITH ENDOCYTIC MACHINERY AND REGULATES THE TRAFFICKING AND FUNCTION OF PRESENILIN

摘要

In accordance with these discoveries, there are provided amino acid fragments of an Arc polypeptide, wherein the fragment binds presenilin 1. Also provided are methods of identifying a compound that inhibits binding of an Arc polypeptide to presenilin 1. Further provided are methods of inhibiting gamma-secretase activity in a cell, as well as inhibiting amyloid beta plaque formation. Finally, there are provided methods of inhibiting the formation of amyloid beta plaques in, on or around neurological tissue in subjects having or is at risk of having a neurodegenerative disease.