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COMPOSITIONS FOR INHIBITION OF PROLIFERATION AND INFILTRATION OF BRAIN TUMOR CELLS BY EXPRESSION OF AMPA-TYPE GLUTAMATE RECEPTOR SUBUNIT
COMPOSITIONS FOR INHIBITION OF PROLIFERATION AND INFILTRATION OF BRAIN TUMOR CELLS BY EXPRESSION OF AMPA-TYPE GLUTAMATE RECEPTOR SUBUNIT
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机译:通过表达AMPA型谷氨酸受体亚单位来抑制脑肿瘤细胞增殖和浸润的组合物
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摘要
The present invention is to provide a method of treatment which inhibits proliferation and invasion of brain tumor cells in developing animal brain tumor cells, and a method for measuring proliferation/invasion activity of brain tumor cells, in the brain tumor cells, preferably, in glioblastoma. Proliferation and invasion of brain tumor cells are inhibited by regulating Ca2+ permeability by glutamate receptor subunits in developing animal brain tumor cells. Regulation of Ca2+ permeability by glutamate receptor subunits can be conducted by introducing the GluR2 gene into AMPA-type glutamate receptors in brain tumor cells. Further, the present invention provides a method for measuring proliferation/invasion activity of brain tumor cells by detecting/measuring the expression of glutamate receptor subunits in developing animal brain tumor cells. IMAGE
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