GENETIC TESTS TO GENOTYPE THE HLA-DRB1 GENE IN SCARRING

摘要

The application relates to methods and genetic tests for determining a patient's likelihood for developing abnormal scarring; particularly raised scarring such as keloid disease and Dupuytren' s disease. A first aspect of the invention provides a method for assessing the likelihood that a subject may develop raised scarring comprising determining whether the subject has a HLA- DRB1 *15 allele. A further aspect of the invention provides a kit for determining whether a subject has a HLA-DRB1* 15 allele comprising: A) means of genotyping the HLA-DRB1 gene; and/or means for determining whether a subject has a direct and/or indirect product of a HLA-DRB1 *15 allele; and B) control polynucleotide and/or polypeptide sample (s) of the HLA-DRB1* 15 allele (s).