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Isolated polynucleotides having a reduced or an increased content of epigenetic control motifs and uses thereof
Isolated polynucleotides having a reduced or an increased content of epigenetic control motifs and uses thereof
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机译:具有减少的或增加的表观遗传控制基序含量的分离的多核苷酸及其用途
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摘要
The present invention is concerned with modified polynucleotides derived from a native gene and having a reduced or increased number of epigenetic control motifs, at the nucleotide level, as compared to the native gene. These polynucleotides are useful to study, increase and/or reduce genes expression, and to improve DNA vaccination methods. The present invention also relates to methods of using these modified polynucleotides in in vitro and in vivo expression systems.
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