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ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-BRIDGED POLYMERIC MICELLE
ENVIRONMENT-RESPONDING siRNA CARRIER USING DISULFIDE-BRIDGED POLYMERIC MICELLE
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机译:使用二硫键桥接的聚合物胶束反应环境的siRNA载体
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摘要
The present invention provides a siRNA-encapsulated polymer micelle complex (a polyion complex), which has high monodispersibility and structural stability and is excellent in the ability of delivering siRNA into a cell. The present invention further provides a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical composition and a gene therapy agent, each of which comprises the complex. The polyion complex of the present invention is characterized by comprising: a block copolymer constituted by a polyethylene glycol portion and a polycation portion having a side chain whose terminus is a thiol group; and siRNA.
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