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Environment-responding siRNA carrier using disulfide-cross-linked polymeric micelle
Environment-responding siRNA carrier using disulfide-cross-linked polymeric micelle
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机译:使用二硫键交联的聚合物胶束的环境响应性siRNA载体
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摘要
Disclosed is a siRNA-encapsulating polymeric micelle complex (a polyion complex) having high monodispersibility and structural stability and excellent in the ability of transporting siRNA into a cell. Further disclosed are a nucleic acid delivery device, a nucleic acid delivery kit, a pharmaceutical composition, and a gene therapy agent, each of which uses the complex. The polyion complex is characterized by comprising: a block copolymer composed of a polyethylene glycol moiety and a polycation moiety having a thiol group as a side chain at the terminus; and siRNA.
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