LIGAND, COMPOSITION FOR UP-REGULATION OF TGF-BETA 1 EXPRESSION AND A METHOD FOR ACTIVATION THE SAME IN VSMC

摘要

The present invention relates to a method of promoting growth factor expressed in the peroxisome conversion by bit via the proliferation activated receptor (PPAR) δ (TGF) -β1 ligands, compositions, and vascular smooth muscle cells (VSCM) inducing, specifically the peroxisome proliferator activated receptor (PPAR) transforming growth factor in vascular smooth muscle cells (VSMC) to activate the δ (TGF) -β1 and promote the expression of the metabolic syndrome, vascular disease, wound healing, skin aging and wrinkles, degenerative It can effectively prevent or treat arthritis, and inflammatory diseases. ; Peroxisome proliferator-activated receptor delta [Peroxisome Proliferator-activated Receptor (PPAR) δ], transforming growth factor beta 1 [Transforming Growth Fctor (TGF)-β1], vascular smooth muscle cells [Vascular Smooth Muscle Cells (VSMC)], Monocyte Chemoattractant Protein (MCP) -1