A porous and hollow silica nanoparticle and a preparation method thereof are provided to show excellent efficiency of drug loading owing to the cavity of the nanoparticle. A method for preparing a porous and hollow silica nanoparticle comprises: a first step of mixing a magnetic nanocluster and a silica precursor; a second step of forming a silica cell portion on the surface of the magnetic nanocluster using the silica precursor; a third step of removing the magnetic nanocluster from the silica cell portion; a fourth step of introducing a surface functional group on the silica cell portion; and a fifth step of surface-modifying the hollow silica nanoparticle with a biocompatible polymer.
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