This invention is a porous hollow silica nanoparticles, a method of manufacturing the same and to a drug delivery system containing the . Porous hollow silica nanoparticles of the present invention, including a large hollow therein, represents a far superior drug loading efficiency compared to the release of various particles used in conventional drug delivery system. Further, the silica nanoparticles of the present invention is a surface functional group and / or an intermediate pore size porous silica negative cells by a biocompatible polymer combined with a surface functional group control to the optimum range, and thus can be continuous and stable release of the drug Since, as a drug delivery system has the advantage that can be used effectively.
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