SYSTEMS-ORIENTED APPROACH FOR PREDICTING DRUG TARGETS IN VIBRIO FAMILY

摘要

PURPOSE: A prediction of drug target of Vibrio sp. using system method is provided to narrow the number of drug target candidate to diseases and combine effective drug target. CONSTITUTION: A method for screening Vibrio sp. drug target enzyme or its gene comprises: a step of constructing metabolic network model of Vibrio sp.; a step of selecting drug target enzyme candidates (I) and (II); a step of selecting overlapped drug target enzyme candidate as a first drug target enzyme group; a step of selecting a second drug target enzyme group; a step of additionally selecting essential metabolites comprising metabolites of which enzyme reaction formula is not related to any human protein; and a step of variously combining among a group comprising the first and second drug target genes.