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NMTR REGULATION BY NMTR(NONSENSE-MEDIATED TRANSLATIONAL REPRESSION) INHIBITOR AND EIF4AIII
NMTR REGULATION BY NMTR(NONSENSE-MEDIATED TRANSLATIONAL REPRESSION) INHIBITOR AND EIF4AIII
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机译:NMTR(无感觉介导的翻译抑制)抑制剂和EIF4AIII对NMTR的调节
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摘要
PURPOSE: A method for regulation NMTR(nonsense-mediated translational repression) by NMTR inhibitor or eIF4AIII is provided to effectively perform quantitation of NMTR.;CONSTITUTION: A method for measuring NMTR(nonsense-mediated translational repression) efficiency comprises: a step of preparing NMRT reporter plasmid containing a reporter gene which operably binds with a target gene; a step of inhibiting NMD-related protein expression; and a step of measuring NMTR reporter protein expression. An NMRT inhibitor contains dominant-negative eIF4AIII with point mutant which threonine, glutamine and leucine are substituted to arginine, valine, and alanine, respectively.;COPYRIGHT KIPO 2010
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