首页>
外国专利>
A method of Obtaining matured dopaminergic neuron from neural precursor cells
A method of Obtaining matured dopaminergic neuron from neural precursor cells
展开▼
机译:从神经前体细胞获得成熟的多巴胺能神经元的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
A method for differentiation of neural precursor cells into matured dopaminergic neuron is provided to produce morphologically and functionally matured dopaminergic neuron, so that the matured dopaminergic neuron is useful for treatment of Parkinson's disease, Alzheimer's disease, cerebral apoplexy and ischemia. The neural precursor cells isolated from ventral midbrain, cortex or lateral ganglionic eminence of mammals, or embryo are differentiated into matured dopaminergic neuron by simultaneously treating the neural precursor cells with Nurr1, Bcl-XL and SHH(sonic hedgehog), or with Nurr1 and bHLH(basic helix-loop-helix) transcription factor selected from neurogenin 1, neurogenin 2, neuro D1, Mash1, MATH 3 and E47 through gene transfer or transduction. Further, the mammals are rodents and human being.
展开▼