ONE STEP HYDROFORMYLATION AND HYDROGENATION PROCESS FOR PREPARING A 1,3-PROPANEDIOL

摘要

(A) ethylene oxide, carbon monoxide, hydrogen, a non-contacting the mixture of water-miscible reaction solvent and the hydroformylation catalyst composition; (B) steps to ensure that phase separation induced by calculating a single-phase reaction product mixture by heating the reaction mixture containing 1,3-propanediol, a temperature decrease; And (c) (ⅰ) a method of adding a phase split-inducing agent to the mixture in combination with a temperature decrease, (ⅱ) first miscibility the addition of a co-solvent, and then the miscible to remove the co-solvent in combination with a temperature decrease, (ⅲ) before the addition of water-miscible co-solvent, and then the miscible to remove the co-solvent, and (ⅳ) the reaction product mixture a cleavage-inducing agent phase to the selected at least one way from a group consisting of a method of adding the the method comprising inducing a separation, where the phase separation is a second phase containing most of the first phase and, 1,3-propanediol, including most of the reaction solvent, the catalyst composition at least 50 wt%, and the unreacted ethylene oxide one step hydroformylation and hydrogenation synthesis of 1,3-propanediol comprising the step, as shown. ; Ethylene oxide, 1,3-propanediol, hydroformylation, hydrogenation, phase separation