To to the invention is already directed to a manufacturing method and a novel intermediate of ruffles, reaction imidapril production method of the present invention is the condensation of a compound of the formula II to the compound represented by the formula (I) represented by the following formula III from the first stage and the intermediate compound to produce an intermediate compound which is to by removing the 4-methoxybenzyl comprises a second step of generating an end product of the formula IV.; [Formula I] ; [FormulaII] ; [FormulaIII] ; [FormulaIV]展开▼