Gene therapy for lung cancer

摘要

Provided is a gene therapy agent for lung cancer using aerosol gene transmission through which lentivirus vector-mediated CTMP(carboxyl terminal modulator protein) inhibits lung carcinoma development. A gene therapy agent for lung cancer using aerosol gene transmission increases expression of p53, p21 and p27 proteins by over-expressing CTMP(carboxyl terminal modulator protein) using lentivirus vector-mediated CTMP and induces expression of proteins wherein PCNA(proliferating cell nuclear antigen) and CDK4(cyclin-dependent kinase 4) are decreased by controlling a cell cycle within a lung. The lentivirus vector-mediated CTMP has SEQ ID NO:1 as forward primer and SEQ ID NO:2 as reverse primer.