THIENOPYRIDINE DERIVATIVES, QUINOLINE DERIVATIVES AND CHINAZOLINE DERIVATIVES HAVING INHIBITOR ACTIVITY WITH RESPECT TO C-MET AUTOPHOSPHORILATION

摘要

1. The compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof:! [Chemical formula 1]! ! where! R1 represents a hydrogen atom or an unsaturated five- or six-membered heterocyclic group, optionally substituted with C1-4 alkyl, C1-4 alkoxy or a halogen atom! R2 represents a hydrogen atom,! X represents CH or N,! Z represents O or S,! E is absent or represents a substituent in the phenylene group selected from a halogen atom, C1-4 alkyl and C1-4 alkoxy, and the numbers indicate the substitution position,! J represents S or O, and! T represents phenyl optionally substituted with a halogen atom, C1-4 alkyl or C1-4 alkoxy; an unsaturated five- or six-membered heterocyclic group optionally substituted with a halogen atom, C1-4 alkyl or C1-4 alkoxy; or an unsaturated nine- or ten-membered bicyclic carbocyclic or heterocyclic group optionally substituted with a halogen atom, C1-4 alkyl or C1-4 alkoxy. ! 2. The compound according to claim 1, where R1 represents a hydrogen atom or an unsaturated five-membered heterocyclic group, optionally substituted with C1-4 alkyl. ! 3. The compound according to claim 1, where R1 represents a hydrogen atom or imidazolyl, optionally substituted with C1-4 alkyl. ! 4. The compound according to claim 1, where R1 represents a hydrogen atom or 1H-imidazol-2-yl, optionally substituted with C1-4 alkyl. ! 5. The compound according to claim 1, where R1 represents a hydrogen atom or is represented by the formula (a):! [Chemical formula 2]! ! where R3 represents a hydrogen atom or C1-4 alkyl. ! 6. The compound according to claim 1, where X represents CH. ! 7. The compound according to claim 1, where Z represents O.! 8. The compound according to claim 1, where