LOCAL VASCULAR DELIVERY OF A PROBULUM, ONE OR IN COMBINATION WITH SIROLIMUS, FOR TREATMENT OF RESTENOSIS, VULNERABLE PLAQUES, AAA (ABDOMINAL AORTIC ANeurysms) AND STROKE

摘要

1. A medical device comprising:! implantable structure; ! a first coating comprising a combination of rapamycin and probucol in therapeutic doses enclosed in a first polymer material, wherein the first coating is attached to the surface of the implantable structure; and! a second coating containing a second polymeric material attached to the first coating to control the elution rate of rapamycin and probucol. ! 2. The medical device according to claim 1, in which the implantable structure contains a stent. ! 3. The medical device according to claim 1, in which the implantable structure contains a stent graft. ! 4. The medical device according to claim 1, wherein the implantable structure comprises an anastomosis device. ! 5. The medical device according to claim 1, in which rapamycin contains sirolimus. ! 6. The medical device according to claim 1, in which the first polymeric material contains at least one non-absorbable polymer. ! 7. The medical device according to claim 1, in which the first polymeric material contains at least one absorbable polymer. ! 8. The medical device according to claim 1, in which the second polymeric material contains at least one non-absorbable polymer. ! 9. The medical device according to claim 1, in which the second polymeric material contains at least one absorbable polymer. ! 10. A medical device comprising:! implantable structure; ! a first coating containing a therapeutic dose of rapamycin and a first polymeric material, wherein the first coating is attached to the surface of the implantable structure; ! a second coating containing a therapeutic dose of probucol and a second polymer material