LOCAL VASCULAR DELIVERY OF PROBUCOL, ALONE OR IN COMBINATION WITH SIROLIMUS, FOR TREATMENT OF RESTENOSIS, VULNERABLE PLAQUES, AAA (ABDOMINAL AORTA ANEURISM) AND STROKE

摘要

FIELD: medicine.SUBSTANCE: invention relates to chemical and pharmaceutical industry and represents implanted medical device, which contains: intra-lumen implanted construction; first coating, containing combination of rapamycin and probucol in therapeutic doses, enclosed in first polymer material, first coating being connected to the surface of intra-lumen implanted construction; and second coating, containing second polymer coating, containing second polymer material, connected to first coating, for regulation of rate of rapamycin and probucol eluting, second polymer material containing fluoropolymer.EFFECT: invention provides treatment and prevention of disease and minimisation of organism response to introduction of medical device, stimulates healing and endoepithelisation, as well as provides control over rates of drug eluting from implanted medical devices and prevents restenosis.49 cl, 7 ex, 97 dwg