NEW FLOROGLUCIN DERIVATIVES ACTIVITIES FOR SELECTIN LIGAND

摘要

1. Pharmaceutical compositions comprising at least one compound of formula (I) and a pharmaceutically acceptable carrier that is useful in medicine! ! where the symbols and substituents have the following meanings:! -X- represents! (a) ! ! where m is 0, 1; n is an integer from 1 to 3; ! (b)! ! where the "ring" represents! ! in which R1 represents H, NO2, CF3, F, Cl, Br, I, CN, CH3, NH2, NHalkyl, NHaryl, NACyl and k is 0, 1; ! (with) ! ! where T represents O, S or [H, H]; p is 0, 1, 2; ! -Y- represents! (a) ! ! where s is 0 or 1,! R2 is CO2H, CO2alkyl, CO2aryl, CO2NH2, CO2aralkyl, SO3H, SO2NH2, PO (OH) 2, 1-H-tetrazolyl-, CHO, COCH3, CH2OH, NH2, NHalkyl, N (alkyl) alkyl, OCH3, CH2OCH3 SH, F, Cl, Br, I, CH3, CH2CH3, CN, CF3; ! R3, independently of R2, is H, CH3, CH2CH3, CF3, F, Cl, Br, I, CN, NO2 and! R4, independently of R2 and R3, is H, CH3, CH2CH3, CF3, F, Cl, Br, I, CN, NO2, R2,! R5 represents H, NO2, CF3, F, Cl, Br, I, CN, CH3, OCH3, SH, NH2! and -W- represents - (CH2-) V, cis-CH = CH- or trans-CH = CH-, where v is 0, 1, 2,! in the case where -W- is cis-CH = CH- or trans-CH = CH-, R2 should not be NH2 or SH; ! (b)! ! where R6, independently of R2, is H, F, Cl, Me, t-Bu, CN, NH2; ! (c)! ! (e)! ! where t is 0, 1, 2; ! -Z represents! (i)! ! R7, independently of R2, is H, NO2, CF3, F, Cl, Br, I, CN, CH3, OCH3, SH, NH2,! (iv)! ! where K is NH, NMe, O, S,! (v)! ! or pharmaceutically acceptable salts, esters or amides and prodrugs of the above compounds of formula (I). ! 2. The pharmaceutical compositions according to claim 1, where the compounds have the formula (II)! ! where -X'- is X (a) or X (b) and -Y has the meanings indicated in claim 1. ! 3. The pharmaceutical compositions according to claim 2, where the compounds have the formula (A) or (B)! ! where -X'- and -Y have the meanings indicated in clause 2, and where