JOSAMYCIN THERAPY FOR ENDOTHELIUM DYSFUNCTION CORRECTION ASSOCIATED WITH L-NAME-INDUCED NITROGEN OXIDE DEFICIENCY

摘要

FIELD: medicine.;SUBSTANCE: invention refers to experimental medicine, particularly to experimental cardiopharmacology and can be used for endothelium dysfunction correction. For this purpose dysfunction is modelled by intraperitoneal introduction of L-nitro-arginine-methyl ester dosed 25 mg/kg daily during 7 days to rats. This therapy is combined with endogastric introduction of macrolide agent Josamycin dosed 10 and 30 mg/kg singly a day.;EFFECT: method provides correction in any antioxidant profile.;1 ex, 1 tbl